MICROBREW-1
Description
MICROBREW-1 (Starbase MicroBrew-1) is a joint experiment by Starbase Brewing and Jaguar Space that investigates fermentation behavior under microgravity conditions aboard the International Space Station. The payload launched on NASA's Crew-11 mission on July 31, 2025, as part of ISS Expedition 73, and returned via NASA's Crew-10.
The experiment mixes wort with top-fermenting yeast in space — launched separately and combined on-orbit — to study the physiological and metabolic processes of fermentation in the absence of sedimentation and buoyancy effects. The central hypothesis is that the lack of sedimentation and buoyancy in microgravity significantly impacts the fermentation efficiency of top-fermenting yeast.
Primary objectives include completing a full fermentation cycle using top-fermenting yeast in microgravity, employing a fermentation model applicable to space exploration, and characterizing changes in yeast behavior and fermentation products resulting from microgravity exposure. Results inform both space applications — biomanufacturing systems for food, medicine, and waste recycling in long-duration missions — and terrestrial improvements to pharmaceutical fermentation, brewing, and bio-based material production.